NMN (Nicotinamide Mononucleotide)
NAD+ precursor that restores cellular NAD+ levels, which decline with age. Central to longevity research but human data is still early.
Evidence by Outcome
NAD+ Levels
Significant increase in blood NAD+ metabolites
Insulin Sensitivity
Improved in prediabetic women (Washington University)
Aerobic Capacity
Modest VO2max improvement in recreational runners
Longevity (human)
No human longevity data yet — animal data promising
Muscle Function
Improved walking speed in elderly (Japan)
Dosing Guide
250-500mg/day
Morning, sublingual or oral
FDA removed NMN from dietary supplement category in 2022. Sublingual may bypass first-pass metabolism.
Safety Profile
Possible Side Effects
- • Generally well-tolerated in trials up to 1200mg/day
Contraindications
- ⚠ Cancer (theoretical — NAD+ supports all cells including cancer)
Known Interactions
Both target aging pathways — NMN via NAD+ restoration, taurine via mitochondrial function. No negative interactions known.
Source: Singh et al., Science 2023; Yoshino et al., Science 2021
NMN boosts NAD+ for electron transport; CoQ10 is a direct electron carrier in the same chain. Complementary mitochondrial support.
Source: Mechanistic rationale
No known interaction. NMN for cellular energy, D3 for immune and bone. Can be taken together.
Source: No interaction data