Omega-3 (EPA/DHA)
Essential polyunsaturated fatty acids with roles in inflammation, cardiovascular function, and brain structure.
Evidence by Outcome
Cardiovascular (high-risk)
25% CVD risk reduction at 4g EPA/day (REDUCE-IT)
Triglycerides
15-30% reduction at 2-4g/day
Depression
SMD -0.61 for EPA-predominant (Translational Psychiatry 2019)
Cognitive Decline Prevention
No clear benefit in healthy adults (Cochrane 2022)
Heart Attack Prevention
28% reduction (VITAL)
Dosing Guide
1-2g combined EPA+DHA/day
With meals containing fat
Triglyceride form absorbs 50% better than ethyl ester. EPA-predominant for mood, DHA for development.
Safety Profile
Possible Side Effects
- • Fishy burps
- • GI discomfort
- • Possible increased bleeding at >3g/day
Contraindications
- ⚠ Anticoagulant therapy (consult physician)
- ⚠ Fish allergy (use algal source)
Known Interactions
Both fat-soluble, both support immune function. Take together with a fatty meal.
Source: Practical co-administration
Omega-3 reduces inflammation; CoQ10 supports mitochondrial energy. Both cardiovascular protective. Take together with fat.
Source: Mechanistic reasoning + both fat-soluble
Omega-3 may enhance vitamin D receptor expression. Both support immune function. Take together with fat.
Source: Nutrients, 2020
Omega-3 anti-inflammatory + ashwagandha adaptogenic. No known negative interaction. Complementary for stress management.
Source: No interaction data; mechanistically complementary
Both cardiovascular protective. K2 prevents calcification, omega-3 reduces inflammation. No negative interaction.
Source: Complementary cardiovascular mechanisms